This page is to inform people of the latest world-wide researches in acupuncture and herbs. The following materials (abstracts only) are cited from other professional journals and websites.
KNEE OSTEOARTHRITIS TREATED WITH ACUPUNCTURE AT THE POINTS SELECTED ACCORDING TO SYNDROME DIFFERENTIATION: A RANDOMIZED CONTROLLED TRIAL
To compare the efficacy difference between acupuncture and western medication in the treatment of knee osteoarthritis.
One hundred and twenty cases were randomly divided into an acupunc ture group and a western medication group, 60 cases in each group. In acupuncture group, acupuncture was applied mainly to Neixiyan (EX-LE 4), Dubi (ST 35), Yinlingquan (SP 9) and Yanglingquan (GB 34) and to the other acupoints selected according to syndrome differentiation. In western medication group, Glucosamine Hydrochloride capsules were applied for oral administration, 2 capsules each time, 3 times per day. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)and Medical Outcomes Study 36-Item Short Form Health Survey (SF-36, Chinese version) were used to assess the therapeutic effect before treatment, after 4 weeks treatment and in follow-up visit of 9 weeks after treatment separately.
After 4 weeks treatment, the total effective rate was 86.7% (52/60) in acupuncture group and was 88.3% (53/60) in western medication group, indicating no statistical significant difference in the comparison between two groups (P > 0.05). In 9 weeks after treatment, the total effective rate was 83.3% (50/60) in acupuncture group, which was better than 61.7% (37/60, P < 0.05) in western medication group. The scores of WOMAC and SF-36 were all improved after treatment as compared with those before treatment in two groups (P < 0.05, P < 0.01). There were no significant differences in comparison between two groups after 4 weeks treatment (all P > 0.05). But, in follow-up visit of 9 weeks after treatment, the scores of WOMAC and SF-36 in acupuncture group were superior to those in western medication group (P < 0.05, P < 0.01).
The short-term efficacies on osteoarthritis of knee in acupuncture group according to syndrome differentiation are similar to that of oral adiministration of Glucosamine Hydrochloride, but the long-term efficacy in acupuncture group is better than that in western medication group.
Fu mu, zhang zhilong. “Knee osteoarthritis treated with acupuncture at the points selected according to syndrome differentiation: a randomized controlled trial” Chinese acupuncture & Moxibustion, Dec. 2011, vol. 31 No. 12
· [Acupuncture and moxibustion for peripheral facial palsy at different stages: multi-central large-sample randomized controlled trial].
To explore the best intervention time of acupuncture and moxibustion for peripheral facial palsy (Bell’s palsy) and the clinical advantage program of selective treatment with acupuncture and moxibustion.
Multi-central large-sample randomized controlled trial was carried out. Nine hundreds cases of Bell’s palsy were randomized into 5 treatment groups, named selective filiform needle group (group A), selective acupuncture + moxibustion group (group B), selective acupuncture + electroacupuncture (group C), selective acupuncture + line-up needling on muscle region of meridian group (group D) and non-selective filiform needle group (group E). Four sessions of treatment were required in each group. Separately, during the enrollment, after 4 sessions of treatment, in 1 month and 3 months of follow-up after treatment, House-Brackmann Scale, Facial Disability Index Scale and Degree of Facial Nerve Paralysis (NFNP) were adopted for efficacy assessment. And the efficacy systematic analysis was provided in view of the intervention time and nerve localization of disease separately.
The curative rates of intervention in acute stage and resting stage were 50.1% (223/445) and 52.1% (162/311), which were superior to recovery stage (25.9%, 35/135) separately. There were no statistical significant differences in efficacy in comparison among 5 treatment programs at the same stage (all P > 0.05). The efficacy of intervention of group A and group E in acute stage was superior to that in recovery stage (both P < 0.01). The difference was significant statistically between the efficacy on the localization above chorda tympani nerve and that on the localization below the nerve in group D (P < 0.01). The efficacy on the localization below chorda tympani nerve was superior to the localization above the nerve.
The best intervention time for the treatment of Bell’s palsy is in acute stage and resting stage, meaning 1 to 3 weeks after occurrence. All of the 5 treatment programs are advantageous to Bell’s palsy. In the condition of the limited medical sources, the simple filiform needle therapy is recommended in acute stage. For the patients with the disorder above chorda tympani nerve, the line-up needling on muscle region of meridian is not recommended.
Li Y. et al.”Acupuncture and moxibustion for peripheral facial palsy at different stages: multi-central large-sample randomized controlled trial” Chinese Acupuncture and Moxibution. 2011 Apr;31(4):289-93.
[PubMed – indexed for MEDLINE]
· CLINICAL OBSERVATION ON 8946 AIDS CASES TREATED BY TRADITIONAL CHINESE MEDICINE
Objective To observe the therapeutic effect of TCM treatment on HIV infected persons and AIDS patients.
Methods The 8946 HIV/AIDS patients treated by TCM in the year 2004~2009 were collected. Symptoms and signs, syndrome distribution, CD4 counting, treatment, case-off, and death of the patients were observed and analyzed 12, 24, 36, and 48 months after treament. Result TCM treatment was very effective in relieving the symptoms such as feverr, asthenia, shortness of breath, loss of appetite, diarrhea, and skin rashes, of which, the improvement of asthenia was most significant. the CD4 counting of the patients in the asymptomatic period decreased along with the time going on, while that of the IDS patients increased along with the time going on. The difference was statistically significant (P<0.05 or P<0.01) after 12, 24, 3, 48 months treament as compared with the baseline. Conclusion TCM therapy is able to enhance and stabilize the immunologic function, improve the symptoms and signs, and improve the survival quality of the patients.
WANG, LIANG, YAN, LU, XU, WANG, FANG, et al. “Clinical Observation on 8946 AIDS cases Treated by Traditional Chinese Medicine.” Journal of Traditional Chinese Medicine. 2011, Vol. 52, No.5
· TCM SYNDROME CHARACTERISTICS OF TYPE A H1N1 FLU
Terms used in the abstract such as “dampness, damp heat, etc.” are traditional chinese medical way to describ a illness. If you have question, please email author or us.
Objective To compare the TCM syndrome characteristics of Type H1N1 Flu with those of the ordinary seasonal flu in the same year in order to guide clinical diagnosis and treament. Methods The data of 200 cases of Type A H1N1 Flu and 200 cases of ordinary seasonal flu in the same year were collected. The cross section investigation on the general clinical manifestations and TCM syndromes of Type A H1N1 Flu group was significantly higher than that of the ordinary seasonal flu cases for analysis. Results The average body temperature of Type A H1N1 Flu group was significantly higher than that of the ordinary seasonal flu group (P<0.05). There was statistical difference between the two groups in the frequency of symptoms including fever, sore throat, heaviness in extremities, heaviness in the head, aversion to wind and cold, chills, headache, obstruction of nose, running nose, and thirst (P<0.01). With the seasonal change, in the Type A H1N1 Flu group, the rate of heaviness in the head, heaviness in extremities, aversion to wind and cold, and chills increased. There was statical significance in summer and autumn as compared with winter (P<0.05 or P<0.01). Conclusion The causative factor of Type A H1N1 Flu is the pathogenic heat combined with damp, and its pathogenesis is that the damp-heat invades the lung, causing a pathogenic condition in which the lung and defensive qi are both diseased, therefore, the exterior syndrome is so short and the pathogen enters the interior so quickly.
LIANG, WU, XIE, LI, LIU, JIANG et. al. “TCM Syndrome Characteristics of Type A H1N1 Flu.” Journal of Traditional Chinese Medicine, 2011, Vol. 52, No.5
· EFFECT OF ELECTROACUPUNCTURE ON QUCHI (LI 11) AND TAICHONG (LR 3) ON BLOOD PRESSURE VARIABILITY IN YOUNG PATIENTS WITH HYPERTENSION
OBJECTIVE: To compare the therapeutic effect of electroacupuncture and western medication on blood pressure variability in young patients with hypertension.
METHODS: Sixty cases of hypertension in young patients were randomized into an electroacupuncture group and a western medication group, 30 cases in each one. In electroacupuncture group, electroacupuncture was applied on Quchi (LI 11) and Taichong (LR 3). In western medication group, Captopril was taken orally. Twenty-four hour dynamic blood pressure, blood pressure variability and day-night rhythm were observed after 14 days treatment in two groups.
RESULTS: Electroacupuncture on Quchi (LI 11) and Taichong (LR 3) reduced systolic pressure and diastolic pressure at different time phases in young patients with hypertension (all P < 0.01), which did not present significant statistical difference as compared with western medication group (all P > 0.05). Electroacupuncture on Quchi (Li, 11) and Taichong (LR 3) reduced apparently the standard deviations of systolic pressure and diastolic pressure at different time phases in young patients with hypertension, indicating significant statistical differences as compared with the deviations before the treatment (P < 0.01, P < 0.05). The statistical significance presented in 24 h systolic standard deviation (24 h SSD), 24 h diastolic standard deviation (24 h DSD), daytime SSD (dSSD), nighttime SSD (nSSD) and nighttime DSD (nDSD) between two groups (P < 0.01, P < 0.05). In comparison of the numbers of Dippers and non-Dippers in two groups, the significant statistical difference presented between two groups after treatment (P < 0.05).
CONCLUSION: Electroacupuncture on Quchi (LI 11) and Taichong (LR 3) has long-term antihypertensive effect and improves effectively day-night rhythm variation in young patients with hypertension. Quchi (LI 11) and Taichong (LR 3) are the effective pair points for hypertension treated with acupuncture.
Yang DH. “Effect of electroacupuncture on Quchi (LI 11) and Taichong (LR 3) on blood pressure variability in young patients with hypertension.” Chinese Acupuncure and Moxibustion.2010,50(7)
· COST-EFFECTIVENESS OF BREECH VERSION BY ACUPUNCTURE-TYPE INTERVENTIONS ON BL 67, INCLUDING MOXIBUSTION, FOR WOMEN WITH A BREECH FOETUS AT 33 WEEKS GESTATION: A MODELLING APPROACH.
OBJECTIVES: To assess, using a modelling approach, the effectiveness and costs of breech version with acupuncture-type interventions on BL67 (BVA-T), including moxibustion, compared to expectant management for women with a foetal breech presentation at 33 weeks gestation. DESIGN: A decision tree was developed to predict the number of caesarean sections prevented by BVA-T compared to expectant management to rectify breech presentation. The model accounted for external cephalic versions (ECV), treatment compliance, and costs for 10,000 simulated breech presentations at 33 weeks gestational age. Event rates were taken from Dutch population data and the international literature, and the relative effectiveness of BVA-T was based on a specific meta-analysis. Sensitivity analyses were conducted to evaluate the robustness of the results. MAIN OUTCOME MEASURES: We calculated percentages of breech presentations at term, caesarean sections, and costs from the third-party payer perspective. Odds ratios (OR) and cost differences of BVA-T versus expectant management were calculated. (Probabilistic) sensitivity analysis and expected value of perfect information analysis were performed. RESULTS: The simulated outcomes demonstrated 32% breech presentations after BVA-T versus 53% with expectant management (OR 0.61, 95% CI 0.43, 0.83). The percentage caesarean section was 37% after BVA-T versus 50% with expectant management (OR 0.73, 95% CI 0.59, 0.88). The mean cost-savings per woman was euro 451 (95% CI euro 109, euro 775; p=0.005) using moxibustion. Sensitivity analysis showed that if 16% or more of women offered moxibustion complied, it was more effective and less costly than expectant management. To prevent one caesarean section, 7 women had to use BVA-T. The expected value of perfect information from further research was euro0.32 per woman. CONCLUSIONS: The results suggest that offering BVA-T to women with a breech foetus at 33 weeks gestation reduces the number of breech presentations at term, thus reducing the number of caesarean sections, and is cost-effective compared to expectant management, including external cephalic version. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Van den Bery I et al. “Cost-effectiveness of breech version by acupuncture-type interventions on BL67, including moxibustion, for women with a breech foetus at 33 weeks gestation: a modelling approach” Complement Ther Med. 2010 Apr;18(2):67-77. Epub 2010 Feb 7.
· GERMAN RANDOMIZED ACUPUNCTURE TRIAL FOR CHRONIC SHOULDER PAIN (GRASP) – A PRAGMATIC, CONTROLLED, PATIENT-BLINDED, MULTI-CENTRE TRIAL IN AN OUTPATIENT CARE ENVIRONMENT.
The German Randomized Acupuncture Trial for chronic shoulder pain (GRASP) comprised 424 outpatients with chronic shoulder pain (CSP) 6weeks and an average pain score of VAS 50mm, who were randomly assigned to receive Chinese acupuncture (verum), sham acupuncture (sham) or conventional conservative orthopaedic treatment (COT). The patients were blinded to the type of acupuncture and treated by 31 office-based orthopaedists trained in acupuncture; all received 15 treatments over 6weeks. The 50% responder rate for pain was measured on a VAS 3months after the end of treatment (primary endpoint) and directly after the end of the treatment (secondary endpoint). Results: In the ITT (n=424) analysis, percentages of responders for the primary endpoint were verum 65% (95% CI 56-74%) (n=100), sham 24% (95% CI 9-39%) (n=32), and COT 37% (95% CI 24-50%) (n=50); secondary endpoint: verum 68% (95% CI 58-77%) (n=92), sham 40% (95% CI 27-53%) (n=53), and COT 28% (95% CI 14-42%) (n=38). The results are significant for verum over sham and verum over COT (p<0.01) for both the primary and secondary endpoints. The PPP analysis of the primary (n=308) and secondary endpoints (n=360) yields similar responder results for verum over sham and verum over COT (p<0.01). Descriptive statistics showed greater improvement of shoulder mobility (abduction and arm-above-head test) for the verum group versus the control group immediately after treatment and after 3months. The trial indicates that Chinese acupuncture is an effective alternative to conventional orthopaedic treatment for CSP. Copyright © 2010. Published by Elsevier B.V.
Molsberger et al. “German randomized acupuncture trial for chronic shoulder pain” Pain. 2010 Jul 22. [Epub ahead of print]
· ACUPUNCTURE FOR PAIN AND DYSFUNCTION AFTER NECK DISSECTION: RESULTS OF A RANDOMIZED CONTROLLED TRIAL.
PURPOSE: To determine whether acupuncture reduces pain and dysfunction in patients with cancer with a history of neck dissection. The secondary objective is to determine whether acupuncture relieves dry mouth in this population. PATIENTS AND METHODS: Patients at a tertiary cancer center with chronic pain or dysfunction attributed to neck dissection were randomly assigned to weekly acupuncture versus usual care (eg, physical therapy, analgesia, and/or anti-inflammatory drugs, per patient preference or physician recommendation) for 4 weeks. The Constant-Murley score, a composite measure of pain, function, and activities of daily living, was the primary outcome measure. Xerostomia, a secondary end point, was assessed using the Xerostomia Inventory. RESULTS: Fifty-eight evaluable patients were accrued and randomly assigned from 2004 to 2007 (28 and 30 patients on acupuncture and control arms, respectively). Constant-Murley scores improved more in the acupuncture group (adjusted difference between groups = 11.2; 95% CI, 3.0 to 19.3; P = .008). Acupuncture produced greater improvement in reported xerostomia (adjusted difference in Xerostomia Inventory = -5.8; 95% CI, -0.9 to -10.7; P = .02). CONCLUSION: Significant reductions in pain, dysfunction, and xerostomia were observed in patients receiving acupuncture versus usual care. Although further study is needed, these data support the potential role of acupuncture in addressing post-neck dissection pain and dysfunction, as well as xerostomia.
Pfister et al. “Acupuncture for pain and dysfunction after neck dissection: reslts of a randomized controlled trial.” J Clin Oncol. 2010 Apr 20.
· SYSTEMATIC EVALUATION OF THERAPEUTIC EFFECT OF ACUPUNCTURE FOR TREATMENT OF SIMPLE OBESITY
OBJECTIVE: To evaluate the therapeutic effect of acupuncture for treatment of simple obesity, and to analyze the current situation of clinical studies. METHODS: Randomized controlled trials (RCTs) involving acupuncture treatment for simple obesity were searched from PubMed (1979-2008), OVID (1979-2008), EBSCO (1973-2008), Cochrane Library (Issue 2, 2008), CBM (1978-2008), CNKI (1979-2008), VIP (1989-2008) and WanFang Database (1998-2008). Literatures were enrolled focusing on RCTs related to acupuncture treatment for simple obesity; the quality of literatures were evaluated by two evaluators unaidedly. Meta-analyses were conducted with the Cochrane Collaboration’s RevMan 4.2.8 software. RESULTS: Eight papers including 1,017 cases, conformed with the enrolled criteria. Meta-analyses showed that there were significant difference between acupuncture groups and western medicine groups in the effective rate [combined RR (fixed effects model) = 1.11, 95% CI (1.05, 1.18), P=0.0006]. There was a significant difference between acupuncture and Sibutramine in the body mass [combined WMD (fixed effects model) = 1.94, 95%CI (1.73, 2.16), P<0.00001] and body mass index (BMI) [combined WMD (fixed effects model) = 0.52, 95% CI (0.33, 0.70), P<0.00001]. However, acupuncture was not superior to Sibutramine in hip circumference (HC) [combined WMD (fixed effects model) = -0.35, 95% CI (-0.56, -0.15), P<0.0007]. CONCLUSION: For treating simple obesity, besides reasonable diet and exercise, acupuncture is safe and effective, which may be more effective than routine western medicine. The quantity of literature was limited and the quality of some literatures was low. Thus, more high-quality and large-scale of RCTs are needed.
LIN, et al. “Systematic evaluation of therapeutic effect of acupuncture for treatment of simple obesity.” Chinese Acupuncture and Moxibustion. 2009 Oct;29(10):856-60.
· GROUP ACUPUNCTURE TO RELIEVE RADIATION INDUCED XEROSTOMIA: A FEASIBILITY STUDY.
BACKGROUND: A distressing complication of radiotherapy treatment for head and neck cancer is xerostomia (chronic oral dryness). Xerostomia is difficult to treat conventionally but there are reports that acupuncture can help. We conducted a feasibility study to examine the acceptability of a standardised group acupuncture technique and adherence to group sessions, together with acceptability of the objective and subjective measurements of xerostomia. METHODS: 12 males with established radiation induced xerostomia were treated in three groups of four. Each received eight weekly sessions of acupuncture using four bilateral acupuncture points (Salivary Gland 2; Modified Point Zero; Shen Men and one point in the distal radial aspect of each index finger (LI1)). Sialometry and quality of life assessments were performed at baseline and at the end of treatment. A semi-structured interview was conducted a week after completing the intervention. RESULTS: Adherence to and acceptability of the treatment and assessments was 100%. There were objective increases in the amounts of saliva produced for 6/12 patients post intervention and the majority also reported subjective improvements. Mean quality of life scores for domains related to salivation and xerostomia also showed improvement. At baseline 92% (11/12) patients reported experiencing a dry mouth “quite a bit/very much” as compared to 42% (5/12) after the treatment. Qualitative data revealed that the patients enjoyed the sessions. CONCLUSION: The pilot study shows that a standardised group technique is deliverable and effective. The tools for objective and subjective assessment are appropriate and acceptable. Further examination in a randomised trial is now warranted.
Simcock, et al. “group acupuncture to relieve radiation induced xerostomia: a feasibility study” Acupunct Med.2009 Sep;27(3):109-13.
· CLINICAL STUDY ON THE EFFECT OF WARMING NEEDLE MOXIBUSTION IN TRIPLE PUNCTURE ON 93 PATIENTS WITH LUMBAR INTERVERTEBRAL DISC HERNIATION
ABSTRACT Objective To observe the effect of warming needle moxibustion in triple puncture on lumbarintervertebral disc herniation. Methods A multi-centered randomized control study was carried out. The 185 patients with lumbar intervertebral disc herniation were assigned to warming needle moxibustion in triple puncture group and general acupuncture group for effect observation, and the pain scores, time-effect of analgesia, immediate effect, and long-term effect were detected according o multiple pain quality (MPQ) scale. Results The effect of warming needle moxibustion in triple puncture qoup in total effective rate, MPQ scores, time effect of analgesia, immediate effect, long-term effect, and relapse rate was significantly different from that of general acupuncture group (P<0.05 or P<0.01). Conclusion Warming needle moxibustion in triple puncture for lumbar intervertebral disc herniation is effective with a shorter time in starting analgesia and longer time in maintaining analgesia.
WU, et al. “Clinical Study on the Effect of Warming Needle Moxibustion in Triple Puncture on 93 Patients with Lumbar Intervertebral Disc Herniation.”(in Chinese) Journal of Traditional Chinese Medicine 2009; 50(12)
· ACUPUNCTURE VERSUS VENLAFAXINE FOR THE MANAGEMENT OF VASOMOTOR SYMPTOMS IN PATIENTS WITH HORMONE RECEPTOR-POSITIVE BREAST CANCER: A RANDOMIZED CONTROLLED TRIAL.
PURPOSE: Vasomotor symptoms are common adverse effects of antiestrogen hormone treatment in conventional breast cancer care. Hormone replacement therapy is contraindicated in patients with breast cancer. Venlafaxine (Effexor), the therapy of choice for these symptoms, has numerous adverse effects. Recent studies suggest acupuncture may be effective in reducing vasomotor symptoms in menopausal women. This randomized controlled trial tested whether acupuncture reduces vasomotor symptoms and produces fewer adverse effects than venlafaxine. PATIENTS AND METHODS: Fifty patients were randomly assigned to receive 12 weeks of acupuncture (n = 25) or venlafaxine (n = 25) treatment. Health outcomes were measured for up to 1 year post-treatment. RESULTS: Both groups exhibited significant decreases in hot flashes, depressive symptoms, and other quality-of-life symptoms, including significant improvements in mental health from pre- to post-treatment. These changes were similar in both groups, indicating that acupuncture was as effective as venlafaxine. By 2 weeks post-treatment, the venlafaxine group experienced significant increases in hot flashes, whereas hot flashes in the acupuncture group remained at low levels. The venlafaxine group experienced 18 incidences of adverse effects (eg, nausea, dry mouth, dizziness, anxiety), whereas the acupuncture group experienced no negative adverse effects. Acupuncture had the additional benefit of increased sex drive in some women, and most reported an improvement in their energy, clarity of thought, and sense of well-being. CONCLUSION: Acupuncture appears to be equivalent to drug therapy in these patients. It is a safe, effective and durable treatment for vasomotor symptoms secondary to long-term antiestrogen hormone use in patients with breast cancer.
Walker et al. “Acupuncture Versus Venlafaxine for the Management of Vasomotor Symptoms in Patients With Hormone Receptor-Positive Breast Cancer: A Randomized Controlled Trial.” J Clin Oncol.2009; 0: JCO.2009.23.5150v1